Copaxone® Did Not Develop Neutralizing Antibodies That Have Been Shown to Affect Clinical Efficacy With Other MS Treatments
September 22, 2003
Source: Teva Neuroscience
Kansas City, Mo.,
Data from a study recently presented at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) conference in Milan, Italy, demonstrated that antibodies to Copaxone® (glatiramer acetate injection) do not interfere with its biological functions.
Most people with relapsing-remitting multiple sclerosis (RRMS) develop the disease between the ages of 20 and 50. With a chronic disease, people may require treatment for decades, making it especially important for patients and physicians to consider the effect of antibodies on treatment outcomes (from both a clinical and biological standpoint).
"The data presented at ECTRIMS showed that the biological functions of Copaxone® were not diminished by Copaxone®-reactive antibodies. The results of this study are consistent with findings from three well- controlled clinical trials, published by Brenner, et. al., that demonstrated Copaxone®-reactive antibodies did not affect the sustained efficacy or safety of Copaxone®," said Dr. Dvora Teitelbaum, Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Copaxone® is indicated for the reduction of the frequency of relapses in relapsing-remitting MS. The most common side effects of Copaxone® are redness, pain, swelling, itching, or a lump at the site of injection, weakness, infection, pain, nausea, joint pain, anxiety, and muscle stiffness.
Copaxone® (glatiramer acetate injection) is now approved in 42 countries worldwide, including the U.S., Canada, Australia, Israel, and all the European countries. In Europe, Copaxone® is marketed by Teva Pharmaceutical Industries Ltd., and Aventis Pharma. In North America, Copaxone® is marketed by Teva Neuroscience.
Teva Pharmaceutical Industries Ltd., headquartered in Israel, is among the top 30 pharmaceutical companies in the world. Close to 90 percent of Teva's sales are in North America and Europe. The company develops, manufactures, and markets generic and branded human pharmaceuticals and active pharmaceutical ingredients. Teva's innovative R&D focuses on developing novel drugs for diseases of the central nervous system.
Teva Pharmaceuticals USA is a subsidiary of Teva Pharmaceutical Industries Ltd. Teva Neuroscience, Inc. is a subsidiary of Teva Pharmaceutical Industries Ltd. Teva Neuroscience, Inc. markets Copaxone®.
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Copaxone® is a registered trademark of Teva Pharmaceutical Industries Ltd.
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