All About Multiple Sclerosis

More MS news articles for September 2003

HHV-6 indirectly harmful to oligodendrocytes

September 24, 2003
Boston Cure Project

Human herpesvirus 6 (HHV-6), particularly the HHV-6A variant, has been found in the brains and the serum of people with MS (see this interview for more information) and therefore is suspected of playing a role in MS. To investigate how the virus might be involved in MS, a group of scientists studied whether T cells infected with HHV-6 might be harmful to oligodendrocytes. They found that substances emitted by T cells infected with HHV-6 increased the level of cell death in oligodendrocytes (but not in astrocytes). Moreover, 6A-infected T cells had a stronger effect than 6B-infected cells. Removal of viral particles and proteins did not reverse the loss of oligodendrocytes. This suggests that HHV-6A may be toxic to oligodendrocytes, not directly but rather through its effect on T cells.

Copyright © 2003, Boston Cure Project