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More MS news articles for September 2003

Temporal lobe epilepsy as a unique manifestation of multiple sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12945947&dopt=Abstract

Can J Neurol Sci. 2003 Aug;30(3):228-32
Gambardella A, Valentino P, Labate A, Sibilia G, Ruscica F, Colosimo E, Nistico R, Messina D, Zappia M, Quattrone A.
Institute of Neurology, School of Medicine, Catanzaro, Italy.

OBJECTIVE:

To report on five patients with temporal lobe epilepsy (TLE) as the unique manifestation of multiple sclerosis (MS).

METHODS:

Among 350 consecutive MS patients, we identified 16/350 (4.6%) who also had epileptic seizures.

Here, we review their electrophysiological and clinical features.

RESULTS:

Five of these 16 patients (four female, one male; mean age 34.2 years; range 31 to 38) with MS and epileptic seizures had an extremely homogeneous clinical picture characterized by TLE as the unique manifestation of MS, even at long follow-up (mean: five years; range 4 to 10).

In all patients, seizures started in the second or third decade.

Brain MRI revealed at least one juxta-cortical lesion within the temporal region.

Antiepileptic medication was always effective.

CONCLUSIONS:

The present study provides the first evidence of a peculiar form of MS characterized by TLE as the unique manifestation of the disease with no disability or MS relapses at long-term follow-up.