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More MS news articles for September 2003

The role of apoptosis in autoimmune encephalomyelitis

Nippon Rinsho. 2003 Aug;61(8):1323-8
Okuda Y, Sakoda S.
Department of Neurology, D-4, Osaka University Graduate School of Medicine.

Experimental autoimmune encephalomyelitis(EAE), an inflammatory demyelinating disease of the central nervous system(CNS) provoked by myelin antigens, is widely used as a model for multiple sclerosis.

Recent studies have shown that apoptosis may contribute to the death of oligodendrocytes and/or neurons, a pathological event leading to neurological deficits.

On the other hand, the apoptotic elimination of inflammatory cells such as T cells and macrophages from the CNS is generally believed to contribute to the spontaneous recovery of EAE.

Thus, apoptosis is involved in the disease-regulating as well as the disease-promoting processes of EAE.