Nippon Rinsho. 2003 Aug;61(8):1416-21
Fukaura H, Kikuchi S.
Department of Neurology, Hokkaido University School of Medicine.
IL-18, previously named interferon-gamma inducing factor, is produced by monocytes/macropharges, dendritic cells, B cells and other APC cells as well as by astrocytes, microglia.
IL-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu.
Caspase-1 regulates the cellular export of IL-18.
Anti IL-18 antibodies prevent EAE.
IL-18 directs autoreactive T cells and promotes autodestruction in CNS via induction of IFN-gamma by NK cells in EAE.
IL-18 is expressed in MS plaque.
Common IL-18 promoter polymorphisms influence the expression on IL-18.
IL-18 is linked to raised IFN-gamma in MS and is induced by activated CD4(+) T cells via CD40-CD40 ligand interaction.
IL-18 in MS is suppressed by treatments such as GA and IFN-beta.