All About Multiple Sclerosis

More MS news articles for September 2003

IL-18 in multiple sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12962032&dopt=Abstract

Nippon Rinsho. 2003 Aug;61(8):1416-21
Fukaura H, Kikuchi S.
Department of Neurology, Hokkaido University School of Medicine.

IL-18, previously named interferon-gamma inducing factor, is produced by monocytes/macropharges, dendritic cells, B cells and other APC cells as well as by astrocytes, microglia.

IL-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu.

Caspase-1 regulates the cellular export of IL-18.

Anti IL-18 antibodies prevent EAE.

IL-18 directs autoreactive T cells and promotes autodestruction in CNS via induction of IFN-gamma by NK cells in EAE.

IL-18 is expressed in MS plaque.

Common IL-18 promoter polymorphisms influence the expression on IL-18.

IL-18 is linked to raised IFN-gamma in MS and is induced by activated CD4(+) T cells via CD40-CD40 ligand interaction.

IL-18 in MS is suppressed by treatments such as GA and IFN-beta.