Arch Phys Med Rehabil. 2003 Sep;84(9):1399-400
Dykstra DD, Pryor J, Goldish G.
Department of Physical Medicine and Rehabilitation, Univeristy of Minnesota, MN 55455, USA.
We describe a patient with multiple sclerosis (MS) who had detrusor hyperreflexia that was not responsive to oral medications or clean intermittent catheterization.
This patient was successfully treated with 2 separate injections of botulinum toxin type B into the bladder.
The results of the treatment lasted 4 months and there were no side effects.
A cystometrogram (CMG) done before the botulinum toxin type B injections showed significant detrusor instability.
A repeat CMG months later showed no detrusor instability.
To our knowledge, this is the first reported successful use of botulinum toxin type B in a patient with detrusor hyperreflexia from MS.