More MS news articles for September 2002

Nastech Receives U.S. Patent for Nasal Delivery Of Apomorphine for Sexual Dysfunction

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Aug. 20, 2002
PRNewswire
BOTHELL, Wash.

Nastech Pharmaceutical Company Inc. (Nasdaq: NSTK) announced today that it was issued U.S. Patent No. 6,436,950, entitled, "Nasal Delivery of Apomorphine." The patent contains thirteen claims and is directed to compositions of apomorphine or a chemically modified equivalent or pharmaceutical salt and to methods of treating sexual dysfunction, including erectile dysfunction. Apomorphine is a potent dopamine agonist that promotes erectile function by stimulating receptors in the hypothalamus.  Nastech has licensed the intranasal apomorphine program for sexual dysfunction on a worldwide basis to Pharmacia Corporation.

"This is the first patent issued to Nastech directed to our intranasal apomorphine program and as such it is an important addition to our growing patent estate," stated Steven C. Quay, M.D., Ph.D., Chairman, President, and Chief Executive Officer.  "Nastech has filed numerous patent applications concerning our drug delivery technologies which are intended to safely and effectively deliver small and large molecule therapeutics.  We intend to continue our focused research and development efforts to further enhance our position as a leader in nasal drug delivery."

Apomorphine acts specifically on the D1/D2 class of dopamine receptors that are responsible for the initiation of the erectile response in the brain. Nastech's nasally administered formulation is the subject of numerous other patent applications in the U.S., European Union countries, Japan, and other major countries.

ERECTILE DYSFUNCTION

ED is defined as the inability to achieve and/or maintain an erection adequate for satisfactory sexual function. Approximately 30 million men in the U.S. and 150 million men worldwide suffer from ED (Deutsche Banc Alex. Brown, June 2001). The ED market is expected to have peak sales of over six billion dollars worldwide. The condition is correlated with increasing age, cardiovascular disease, hypertension, diabetes, hyperlipidemia and smoking. In addition, neurogenic risk factors such as radical prostatectomy, spinal cord injury and multiple sclerosis, certain prescription drugs, and psychogenic issues may contribute to ED.

ABOUT NASTECH

Nastech Pharmaceutical Company Inc., recognized worldwide as a leader in nasal drug delivery technology, is dedicated to improving patient care by using "Formulation Science," a systematic approach to drug development using biophysics, physical chemistry, and pharmacology to improve efficacy and safety, and to provide new therapeutic options.  Additional information on Nastech is available at http://www.nastech.com/ .

NASTECH SAFE HARBOR STATEMENT

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 including, without limitation, statements regarding the following: (a) the Company's success in its various pre-clinical and clinical development programs; (b) the future capacity of the Company's Seattle facility; (c) the Company's future plans to market and sell Nascobal; (d) the Company's discussion with potential pre-clinical and clinical partners; and (e) the Company's achievement of its 2002 corporate objectives.  These statements are subject to a variety of risks and uncertainties.  There are a number of important factors that could cause actual results to differ materially from those projected or suggested in any forward-looking statement made by the Company. These factors include, but are not limited to: (i) the Company's and/or the Company's partner's ability to successfully complete product research and development, including pre-clinical and clinical studies and commercialization;  (ii) the Company's and/or the Company's partner's ability to obtain required governmental approvals, including product and patent approvals; (iii) the Company's ability to attract and/or maintain manufacturing, sales, distribution and marketing partners; and (iv) the Company's and/or the Company's partner's ability to develop and commercialize products before its competitors.  In addition, significant fluctuations in quarterly results may occur as a result of the timing of milestone payments and the timing of costs and expenses related to the Company's research and development program.  A detailed discussion of additional factors that could cause actual results to differ materially from those projected or suggested in any forward-looking statements is contained in the Company's filings with the Securities and Exchange Commission, including those factors discussed under the caption "Risk Factors" in the Company's most recent Annual Report on Form 10-K.  Nastech undertakes no obligation to update forward- looking statements to reflect events or circumstances occurring after the date of this press release.
 

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