Cytokine Growth Factor Rev 2002 Aug;13(4-5):379
Department of Molecular Genetics, Chiba University Graduate School of Medicine, 1-8-1 Inohana, 260-8670, Chiba, Japan
Type I interferons (IFN-alpha/beta) are produced upon viral and bacterial infections and play essential roles in host defense.
However, since IFN-alpha/beta have multiple regulatory functions on innate and adoptive immunity, dysregulation of the IFN-alpha/beta system both in uninfected hosts and during immune responses against infection can result in immunopathologies.
In fact, IFN-alpha/beta therapy often accompanies autoimmune-like symptoms.
In this regard, we have recently found that mice lacking IFN regulatory factor (IRF)-2, a negative regulator of IFN-alpha/beta signaling, develop spontaneous, CD8(+) T cell-dependent skin inflammation.
This unique animal model, together with other animal models, highlights the importance of the mechanism maintaining the homeostasis in the IFN-alpha/beta system even in the absence of infection.