J Neurol Sci 2002 Oct 15;202(1-2):93
Myhr K, Vagnes K, Maroy T, Aarseth J, Nyland H, Vedeler C.
The Multiple Sclerosis National Competence Centre, Department of Neurology, Haukeland Hospital, University of Bergen, N-5021, Bergen, Norway
The expression level of interleukin-10 (IL-10) is related to polymorphisms -1082 (G/A), -819 (T/C) and -592 (A/C) in the promoter region of the IL-10 gene.
The distribution of these polymorphisms was analyzed to determine whether they could influence disease susceptibility or clinical course in multiple sclerosis (MS).
The -1082 (G/A), -819 (T/C) and -592 (A/C) genotypes were similarly distributed between MS patients and the controls.
The primary progressive MS patients with the low IL-10 expression haplotype showed a trend towards a worse clinical outcome than did patients with medium- or high-expression haplotypes (P=0.056).
The polymorphisms did not influence the clinical course in patients with relapsing-remitting MS.