Nat Immunol 2002 Sep 3
Fillatreau S, Sweenie CH, McGeachy MJ, Gray D, Anderton SM.
University of Edinburgh, Institute of Cell, Animal and Population Biology, King's Buildings West Mains Road, Edinburgh EH9 3JT, UK.
To assess the importance of B cell control of T cell differentiation, we analyzed the course of the T helper type 1 (T(H)1)-driven disease experimental autoimmune encephalomyelitis in mice with an altered B cell compartment.
We found that recovery was dependent on the presence of autoantigen-reactive B cells.
B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen.
With a bone marrow chimeric system, we generated mice in which IL-10 deficiency was restricted to B cells but not T cells.
In the absence of IL-10 production by B cells, the pro-inflammatory type 1 immune response persisted and mice did not recover.
These data show that B cell#150;derived IL-10 plays a key role in controlling autoimmunity.