J Neurosci 2001 Sep 15;21(18):7046-52
Mason JL, Suzuki K, Chaplin DD, Matsushima
GK.
Curriculum in Neurobiology and the
University of North Carolina Neuroscience Center, Chapel Hill, North Carolina
27599, USA.
Interleukin-1beta (IL-1beta) is a
proinflammatory cytokine associated with the pathophysiology of demyelinating
disorders such as multiple sclerosis and viral infections of the CNS.
However, we demonstrate here that
IL-1beta appears to promote remyelination in the adult CNS.
In IL-1beta(-/-) mice, acute demyelination
progressed similarly to wild-type mice and showed parallel mature oligodendrocyte
depletion, microglia-macrophage accumulation, and the appearance of oligodendrocyte
precursors.
In contrast, IL-1beta(-/-) mice failed
to remyelinate properly, and this appeared to correlate with a lack of
insulin-like growth factor-1 (IGF-1) production by microglia-macrophages
and astrocytes and to a profound delay of precursors to differentiate into
mature oligodendrocytes.
Thus, IL-1beta may be crucial to
the repair of the CNS, presumably through the induction of astrocyte and
microglia-macrophage-derived IGF-1.
PMID: 11549714