More MS news articles for Sep 2001

Interleukin-1beta promotes repair of the CNS

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11549714&dopt=Abstract

J Neurosci 2001 Sep 15;21(18):7046-52

Mason JL, Suzuki K, Chaplin DD, Matsushima GK.

Curriculum in Neurobiology and the University of North Carolina Neuroscience Center, Chapel Hill, North Carolina 27599, USA.

Interleukin-1beta (IL-1beta) is a proinflammatory cytokine associated with the pathophysiology of demyelinating disorders such as multiple sclerosis and viral infections of the CNS.

However, we demonstrate here that IL-1beta appears to promote remyelination in the adult CNS.

In IL-1beta(-/-) mice, acute demyelination progressed similarly to wild-type mice and showed parallel mature oligodendrocyte depletion, microglia-macrophage accumulation, and the appearance of oligodendrocyte precursors.

In contrast, IL-1beta(-/-) mice failed to remyelinate properly, and this appeared to correlate with a lack of insulin-like growth factor-1 (IGF-1) production by microglia-macrophages and astrocytes and to a profound delay of precursors to differentiate into mature oligodendrocytes.

Thus, IL-1beta may be crucial to the repair of the CNS, presumably through the induction of astrocyte and microglia-macrophage-derived IGF-1.

PMID: 11549714