More MS news articles for Sep 2001

Grey matter abnormalities in multiple sclerosis: proton magnetic resonance spectroscopic imaging

http://www.ingenta.com/isis/searching/ExpandTOC/ingenta?issue=infobike://arn/ms/2001/00000007/00000004&index=2&WebLogicSession=O5e0eAZS8rT2IGCXIhFJ|6040873963134832242/-1052814329/6/7051/7051/7052/7052/7051/-1

Multiple Sclerosis,  August 2001, vol. 7, no. 4,   pp. 221-226(6)
 
Sharma R. [1]; Narayana P.A. [1] *; Wolinsky J.S. [2]
 
[1] Department of Radiology, University of Texas at Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA [2] Department of Neurology, University of Texas at Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA [*] Correspondence: PA Narayana
 
Abstract:

Pathologically defined abnormalities in the cortical gray matter (GM) are well described in multiple sclerosis (MS) but are infrequently seen by conventional magnetic resonance imaging (MRI).

We systematically evaluated 52 relapsing remitting MS patients and 20 normal volunteers with high resolution MRI and short echo proton magnetic resonance spectroscopic imaging (MRSI).

Individual tissue contributions to the spectroscopic voxels were estimated based on MRI that incorporated both CSF suppression and magnetization transfer, or double inversion images in which both CSF and GM were suppressed.

Strong resonances in the 0.8 to 1.5 p.p.m. spectral region were observed in 13 MS patients.

Image segmentation based on the MRI characteristics of tissues contributing to the spectroscopic voxels showed that these additional peaks originated mainly from GM.

The presence of these additional peaks suggests that the normal appearance GM on MRI, is biochemically abnormal in a substantial proportion of relapsing remitting MS patients.