Int MS J. 2003 Jun;10(2):38-42
Dwosh E, Guimond C, Duquette P, Sadovnick AD.
Department of Medical Genetics, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada.
Previous research on the effects of pregnancy on multiple sclerosis (MS) is somewhat flawed, and well-controlled, well-designed studies are needed to validate trial findings.
In general, pregnancy appears to have a protective effect on MS course, with fewer, less severe relapses, especially in the third trimester.
The exacerbation rate is increased in the first 3 months after delivery, but the overall relapse rate is no different to that observed in non-pregnant MS patients.
A woman's past history of relapses may be the best indicator of clinical course during and immediately after pregnancy.
Pregnancy does not appear to affect the long-term course of MS.