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More MS news articles for October 2003

A whole genome screen for association in Polish multiple sclerosis patients

J Neuroimmunol. 2003 Oct;143(1-2):107-11
Bielecki B, Mycko MP, Tronczynska E, Bieniek M, Sawcer S, Setakis E, Benediktsson K, Compston A, Selmaj KW.
Department of Neurology, Medical University of Lodz, 22 Kopcinskiego Street, 90-153, Lodz, Poland

We have performed the first systematic search for MS susceptibility genes completed in the Polish population.

This screen was performed using 6000 microsatellite markers typed in pooled DNA from cases (n=200), controls (n=200) and trio families (n=129).

Five associated markers are identified, one (D6S2444) from the HLA region and four are from novel regions not previously associated with MS, 2p16 (D2S2153), 3p13 (D3S3568), 7p22 (D7S2521) and 15q26 (D15S649).