All About Multiple Sclerosis

More MS news articles for October 2003

A genome-wide screen for association in Hungarian multiple sclerosis

J Neuroimmunol. 2003 Oct;143(1-2):84-7
Rajda C, Bencsik K, Seres E, Jonasdottir A, Foltynie T, Sawcer S, Benediktsson K, Fossdal R, Setakis E, Compston A, Vecsei L.
Department of Neurology, University of Szeged, Semmelweis u. 6, H-6725, Szeged, Hungary

Although the pathogenesis of multiple sclerosis (MS) is not fully understood, substantial evidence points to the involvement of genetic factors.

We report on a genome-wide screen for disease association in the Hungarian population using 5532 microsatellite markers.

These markers were typed in DNA pools that consisted of 88 MS patients (cases), and 128 unrelated controls.

Based on a stringent selection criterion, we obtained 33 markers suggesting association with the disease.