All About Multiple Sclerosis

More MS news articles for October 2003

New candidate loci for multiple sclerosis susceptibility revealed by a whole genome association screen in a Belgian population

J Neuroimmunol. 2003 Oct;143(1-2):65-9
Goris A, Sawcer S, Vandenbroeck K, Carton H, Billiau A, Setakis E, Compston A, Dubois B.
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000, Leuven, Belgium

We have completed a whole genome screen for association with multiple sclerosis (MS) in a Belgian population.

The 6000 microsatellite markers provided through the Genetic Association of Multiple Sclerosis in EuropeanS (GAMES) collaborative were genotyped in case-control and family-based samples.

The 20 most promising markers included three markers (D6S1615, D6S2444 and TNFa) from the classically established HLA class II cluster and one (D6S265) from the recently re-emphasized HLA class I cluster.

In other highlighted regions, preliminary candidate genes from the immune system have been identified: e.g.

the integrin ligand EDIL3, the high-mobility group box protein TOX, neutral sphingomyelinase activating factor (NSMAF) and the B-cell specific transcription factor POU2AF1.