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More MS news articles for October 2003

Autoantibodies to serotonin in serum of patients with psychiatric disorders

Psychiatry Res. 2003 Nov 1;121(1):51-7
Schott K, Schaefer JE, Richartz E, Batra A, Eusterschulte B, Klein R, Berg PA, Bartels M, Mann K, Buchkremer G.
Department of Psychiatry and Psychotherapy, University of Tubingen, Osianderstr. 24, D-72076, Tubingen, Federal Republic of Germany

Antibodies to serotonin in serum were investigated by ELISA in patients with paranoid schizophrenia (N=27), schizoaffective psychosis (N=38), depression (N=67), Alzheimer's disease (N=21), chronic alcoholism (N=43), rheumatoid arthritis (N=25), and multiple sclerosis (N=16), and in healthy volunteers (N=60).

Increased antibody reactivity to serotonin was found in schizoaffective psychosis, chronic alcoholism, and rheumatoid arthritis.

Decreased antibody reactivity to serotonin was found in multiple sclerosis and depression.

These anti-serotonin antibodies belong to the class of so-called natural autoantibodies.

Alterations of these natural autoantibodies could indicate a disturbance to the immune system.

It is possible that these antibodies could also influence receptor function.

Autoantibodies to neurotransmitters in a wide spectrum of psychiatric disorders have not previously been reported.