All About Multiple Sclerosis

More MS news articles for October 2002

Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems

Med Hypotheses 2002 Nov;59(5):594
Loder C, Allawi J, Horrobin D.
Sunnydene, Farncombe, Surrey, England, UK

In a randomized, placebo-controlled double-blind trial a combination of lofepramine, phenylalanine and vitamin B(12) was found to be effective in relieving the symptoms of multiple sclerosis (MS).

The effect occurred within 2-4 weeks, and improved all types of symptoms in all types of MS.

The combination was also effective in relieving symptoms in patients with chronic pain and chronic fatigue.

We hypothesize that the action of this combined therapy may relate to activation of the noradrenergic locus coeruleus/lateral tegmentum (LC/LT) system which has the potential to influence the functioning of large areas of the brain and spinal cord.