Neurology 2002 Oct 8;59(7):1071-3
Sotgiu S, Serra C, Mameli G, Pugliatti M, Rosati G, Arru G, Dolei A.
Institute of Clinical Neurology (Drs. Sotgiu, Pugliatti, Rosati, and Arru) and Section of Microbiology, Department of Biomedical Sciences (Drs. Serra, Mameli, and Dolei), University of Sassari, Italy.
MS-associated retrovirus (MSRV) in the CSF may have gliotoxic properties and could be associated with a more disabling MS.
The authors tested this hypothesis in 15 untreated patients with MS: 6 MSRV- and 9 MSRV+ at the time of CSF withdrawal.
After a 3-year mean follow-up, MSRV- patients showed a stable MS course, whereas MSRV+ patients had a progressive course (p = 0.01).