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Arq Neuropsiquiatr 2002 Sep;60(3B):875-880
Moreira MA, Lana-Peixoto MA, Callegaro D, Haussen SR, Gama PD, Gabbai AA, Rocha FC, Lino AM.
Multiple sclerosis is an inflammatory disease in which immunological mechanisms play an important role in causing demyelinating lesions in the central nervous system.
A number of drugs acting in different stages of these mechanisms have been tested for its treatment.
This paper analyses the most important clinical trials with glucocorticoids and immunomodulatory treatments, including human immunoglobulin, using the classes of evidences and types of recommendations as have been defined and widely accepted by the international scientific community.
It aims to provide sufficient information to support the BCTRIMS Expanded Consensus on Treatment of MS.