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More MS news articles for October 2002

Anti-heparan sulfate antibodies in neurological disease

Muscle Nerve 2002 Nov;26(5):713-5
Briani C, Ruggero S, Alaedini A, Nardelli E, Ferrari S, Wirguin I, Zara G, Battistin L, Latov N.
Department of Neurological and Psychiatric Sciences, University of Padova, Via Giustiniani 5, 35128 Padova, Italy.

Antibodies to heparan sulfate (HS) have previously been found in association with peripheral neuropathy.

We tested sera from patients with neuropathies and with other neurological diseases for antibodies to HS using an avidin-biotin enzyme-linked immunosorbent assay (ELISA) system.

Increased titers of anti-HS antibodies were found in 3.4% of patients with neuropathy, and in 3% of patients with other neurological diseases.

In all cases, however, an inflammatory disease was present, including chronic inflammatory neuropathy, cerebral vasculitis, or multiple sclerosis.

Antibodies to HS appear not to be specific for neuropathy, as they occur in several inflammatory diseases.

They might contribute to the associated breakdown of the blood-brain or blood-nerve barrier.