European Neurology 46:3:2001, 153-155.
E. Prasa, I. Aksentijevichd, Y. Shinarb, D.L. Kastnerd, A. Achironc
a Danek Gertner Institute of Human Genetics,
b Heller Institute of Medical Science,
c Multiple Sclerosis Clinic, Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
d Genetic Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Md., USA
Multiple sclerosis (MS) is a multifactorial disease with a documented genetic component.
Recent experimental models suggested a role for the tumor necrosis factor receptor 1 (TNFR1) in the pathogenesis of the disease.
We compared the frequency of two polymorphisms from TNFR1, located in exon 1 and intron 6, in 94 Jewish Ashkenazi MS patients and 83 healthy Ashkenazi controls.
No significant differences were observed for both polymorphisms between the patients and the controls.
These findings suggest that genetic
variants in TNFR1 do not play a significant role in Ashkenazi Jews.
Copyright © 2001 S. Karger AG,