Brain, Vol. 124, No. 11, 2147-2161,
Masato Mitome (1),*, Hoi Pang Low (1), Anthony van den Pol (3), John J. Nunnari (2), Merrill K. Wolf (1,2), Susan Billings-Gagliardi (1,2) and William J. Schwartz (1)
1 Departments of Neurology, and
2 Cell Biology, University of Massachusetts Medical School, Worcester and
3 Department of Neurosurgery, Yale University School of Medicine, New Haven, USA
Epidermal growth factor-responsive neural precursor cells were used as donor cells for transplantation into wild-type and myelin-deficient shiverer (shi) mice.
The cells engrafted robustly within the CNS following intracerebroventricular and cisternal transplantation in neonatal mice.
The cells adopted glial phenotypes, and some functioned as oligodendrocytes, producing myelin basic protein and morphologically normal internodal myelin sheaths.
When individual shi mice received two transplants (on post-natal days 1 and 3), donor-derived cells disseminated widely and expressed myelin basic protein in central white matter tracts throughout the brain.
Correspondence to: William J. Schwartz,
Department of Neurology, University of Massachusetts Medical School, 55
Lake Avenue North, Worcester, MA 01655, USA E-mail: email@example.com
Copyright © 2001 Oxford University
Copyright © 2001 Oxford University Press.