More MS news articles for Oct 2001

Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MS

J Neuroimmunol 2001 Sep 3;119(1):145-9 Related Articles, Books, LinkOut
Makhlouf K, Weiner HL, Khoury SJ.
Center for Neurologic Diseases, Brigham and Women's Hospital, and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Interleukin (IL)-12 is a cytokine thought to play a major role in the pathogenesis of multiple sclerosis (MS).

We have previously shown that patients with progressive MS have a high percentage of IL-12-producing monocytes in the blood compared to normal individuals.

We analyzed 269 blood samples from 189 MS patients for the percentage of IL-12-producing monocytes.

We found that the increased IL-12 expression correlates with disability, as measured by the Expanded Disability Status Scale (EDSS), and with disease activity, measured by the presence of gadolinium-enhancing magnetic resonance imaging (MRI) lesions.

Grant support:

PMID: 11525812 [PubMed - indexed for MEDLINE]