J Neuroimmunol 2001 Sep 3;119(1):145-9
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Makhlouf K, Weiner HL, Khoury SJ.
Center for Neurologic Diseases, Brigham and Women's Hospital, and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Interleukin (IL)-12 is a cytokine thought to play a major role in the pathogenesis of multiple sclerosis (MS).
We have previously shown that patients with progressive MS have a high percentage of IL-12-producing monocytes in the blood compared to normal individuals.
We analyzed 269 blood samples from 189 MS patients for the percentage of IL-12-producing monocytes.
We found that the increased IL-12 expression correlates with disability, as measured by the Expanded Disability Status Scale (EDSS), and with disease activity, measured by the presence of gadolinium-enhancing magnetic resonance imaging (MRI) lesions.
PMID: 11525812 [PubMed - indexed
PMID: 11525812 [PubMed - indexed for MEDLINE]