More MS news articles for Oct 2001

Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11558796&form=6&db=m&Dopt=r

Ann Neurol 2001 Sep;50(3):389-400
Peterson JW, Bo L, Mork S, Chang A, Trapp BD.
Neurosciences Graduate Studies Program, Ohio State University, Columbus, USA.

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system that causes motor, sensory, and cognitive deficits.

The present study characterized demyelinated lesions in the cerebral cortex of MS patients.

One hundred twelve cortical lesions were identified in 110 tissue blocks from 50 MS patients.

Three patterns of cortical demyelination were identified:

Inflammation and neuronal pathology were studied in tissue from 8 and 7 patients, respectively.

Compared to white matter lesions, cortical lesions contained 13 times fewer CD3-positive lymphocytes (195 vs 2,596/mm3 of tissue) and 6 times fewer CD68-positive microglia/macrophages (11,948 vs 67,956/mm3 of tissue).

Transected neurites (both axons and dendrites) occurred at a density of 4,119/mm3 in active cortical lesions, 1,107/mm3 in chronic active cortical lesions, 25/mm3 in chronic inactive cortical lesions, 8/mm3 in myelinated MS cortex, and 1/mm3 in control cortex.

In active and chronic active cortical lesions, activated microglia closely apposed and ensheathed apical dendrites, neurites, and neuronal perikarya.

In addition, apoptotic neurons were increased significantly in demyelinated cortex compared to myelinated cortex.

These data support the hypothesis that demyelination, axonal transection, dendritic transection, and apoptotic loss of neurons in the cerebral cortex contribute to neurological dysfunction in MS patients.

Grant support:
RO1 NS35058/NS/NINDS
NS07291/NS/NINDS

PMID: 11558796 [PubMed - in process]