Multiple Sclerosis, 1 December 2003, vol. 9, no. 6, pp. 579-584(6)
Nakane S.; Matsuo H.; Goto H.; Yoshinaga-Matsumoto M.; Ohtsuru I.; Ichinose K.; Onodera H.; Yoshida M.; Shibuya N.
 Department of Neurology, Kawatana National Hospital, Nagasaki, Japan  Department of Neurology and Division of Clinical Research, Kawatana National Hospital, Nagasaki, Japan  Department of Surgery, Kawatana National Hospital, Nagasaki, Japan  Research and Development Laboratory, Asahi Medical Co., Ltd., Oita, Japan
Experimental autoimmune encephalomyelitis (EAE) is a major animal model of human multiple sclerosis (MS).
CD4+ T cells are thought to play a pivotal role in the pathogenesis of EAE and MS.
In order to investigate the depletion of CD4+ T cells from the systemic circulation as an effective strategy for the treatment of MS, we performed extracorporeal CD4+ T cell adsorption, using a filter to which anti-CD4+ antibody is immobilized as a ligand, in adoptively transferred EAE.
Rats treated with CD4+ T cell removal filter (CD4RF) exhibited milder clinical signs of EAE and earlier recovery than those receiving sham treatment.
Moreover, the thymic cells from EAE rats treated with CD4RF exhibited a suppressed proliferative response and IFN-g production to myelin basic protein.
These results suggest that depletion of CD4+ T cells from the systemic circulation by extracorporeal treatment is a potentially useful strategy for treatment of acute phase and relapsing MS.