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More MS news articles for November 2003

Changes of percentages in immune cells phenotypes and cytokines production during two-year IFN-beta-1a treatment in multiple sclerosis patients

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14586608&dopt=Abstract

J Neurol. 2003 Oct;250(10):1229-36
Mirowska D, Skierski J, Paz A, Koronkiewicz M, Zaborski J, Kruszewska J, Czlonkowski A, Czlonkowska A.
2nd Dept. of Neurology, Institute of Psychiatry & Neurology, Sobieskiego 1/9, Warsaw, Poland.

OBJECTIVE:

The aim of the study was to find out whether INF-beta-1a influences the immune profile of peripheral blood (PB) leukocytes in MS patients.

METHOD:

We have studied 20 patients with relapsing-remitting form of MS treated with INF-beta-1a using twocolor cytometry.

We determined immune cells phenotypes and production of some cytokines: IL-4, IL-10, IL-12, IFN-gamma, before drug administration and after starting the treatment.

RESULTS:

In MS patients an increased percentage of CD14(+)CD86(+) cells and CD3(+)CD25(+) cells was noticed after 6, 9 and 12 months of INF-beta-1a therapy.

Among cytokine-producing cells we noted an increased fraction of CD3(+)IL-4, CD14(+)IL-10 and CD14(+)IL-12 cells after 12 months, which decreased to the level observed before treatment after 24-month therapy.

CONCLUSIONS:

IFN-beta-1a treatment was associated with significant changes in immune response.

This effect was mostly evident within the first year of treatment.