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Human herpesvirus 6

Expert Rev Mol Med. 1997 Nov 5;1:1-17
Dewhurst S, Skrincosky D, van Loon N.
Department of Microbiology and Immunology, and Cancer Center, University of Rochester Medical Center, 575 Elmwood Avenue, Box 672, Rochester, NY 14642, USA.

Human herpesvirus 6 (HHV-6) is a T-lymphotropic herpesvirus, which infects almost all children by the age of two years and persists lifelong.

Two distinct variants of HHV-6, HHV-6A and HHV-6B, have been described, and the latter has been shown to be a common cause of acute febrile illnesses in young children, including exanthem subitum (roseola).

HHV-6 has also been associated with a number of neurological disorders, including encephalitis and seizures, and the virus has been postulated to play a role in acquired immunodeficiency syndrome (AIDS), multiple sclerosis (MS) and chronic fatigue immunodeficiency syndrome (CFIDS).

This review provides a critical summary of research conducted on HHV-6.