All About Multiple Sclerosis

More MS news articles for November 2003

Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

J Allergy Clin Immunol. 2003 Nov;112(5):837-49
Chitnis T, Khoury SJ.
Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA.

Multiple sclerosis is an immune-mediated disorder of the central nervous system.

T lymphocytes are thought to play a central role in the initiation and potentially in the propagation of this disease.

Two signals are required for T-cell activation.

The first signal consists of the interaction of the T-cell receptor with antigen presented by the MHC molecule on antigen-presenting cells.

The second signal requires engagement of costimulatory receptors on T cells with their ligands on antigen-presenting cells.

Several costimulatory pathways have been shown to play an important role in T-lymphocyte activation.

Here we will review the current literature on the contribution of the B7-1/2-CD28/CTLA-4, inducible costimulatory molecule-B7h, programmed death pathway 1-programmed death pathway ligand 1/ligand 2, CD40-CD154, OX40-OX40 ligand, and CD137-CD137 ligand pathways to the pathogenesis of multiple sclerosis and their potential roles as therapeutic targets.