Eur Psychiatry. 2003 Oct;18(6):318-9
Himmerich H, Szegedi A, Klawe C, Anghelescu I, Muller MJ.
Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804, Munich,
Germany
A female patient with multiple sclerosis (MS) suffered from an acute psychotic disorder after taking distigmine bromide for detrusor dysfunction.
She showed a dramatic relief of her symptoms after the medication, distigmine bromide, was stopped.
Distigmine is not supposed to penetrate the blood-brain barrier (BBB).
However, in MS patients a leakage of the BBB could be hypothesized.