All About Multiple Sclerosis

More MS news articles for November 2003

Distigmine bromide induced acute psychotic disorder in a patient with multiple sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14611928&dopt=Abstract

Eur Psychiatry. 2003 Oct;18(6):318-9
Himmerich H, Szegedi A, Klawe C, Anghelescu I, Muller MJ.
Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804, Munich, Germany

A female patient with multiple sclerosis (MS) suffered from an acute psychotic disorder after taking distigmine bromide for detrusor dysfunction.

She showed a dramatic relief of her symptoms after the medication, distigmine bromide, was stopped.

Distigmine is not supposed to penetrate the blood-brain barrier (BBB).

However, in MS patients a leakage of the BBB could be hypothesized.