All About Multiple Sclerosis

More MS news articles for November 2003

Genomic and proteomic analysis of multiple sclerosis. Opinion

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14630200&dopt=Abstract

Curr Opin Immunol. 2003 Dec;15(6):660-7
Robinson WH, Utz PJ, Steinman L.
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 94305, Stanford, CA, USA

Multiple sclerosis (MS) and other autoimmune diseases result from the dysregulation of genetic and proteomic programs.

In MS, the loss of immune homeostasis leads to aberrant targeting and destruction of the myelin sheath, which manifests as the clinical syndrome of MS.

The advent of technologies to perform large-scale analysis of mRNA transcript and protein expression will transform our understanding of the mechanisms underlying the initiation and progression of MS, and will yield new targets for therapeutic intervention.