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More MS news articles for November 2003

Multiple sclerosis siblings with cerebrospinal fluid immunopathy but without any indication of neuronal damage

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14616300&dopt=Abstract

Acta Neurol Scand. 2003 Nov;108(5):319-22
Haghighi S, Frisen L, Oden A, Andersen O.
Institute of Clinical Neurosience, Sahlgrenska University Hospital, Goteborg, Sweden

OBJECTIVE:

In a previous study, we found that nine of the 47 siblings to multiple sclerosis (MS) patients with a normal neurologic examination carry an intrathecal oligoclonal immunopathy with limited specificity, a condition we termed MS immunopathic trait.

Here we searched for neurological dysfunction with increased sensitivity.

METHOD:

We used high-pass resolution perimetry, which reveals visual pathway lesions by their impaired neural effective capacity (EC) in early MS cases even without optic neuritis.

RESULTS:

These nine individuals with MS immunopathic trait did not differ from nine healthy controls with normal cerebrospinal fluid regarding their EC.

CONCLUSION:

This is further evidence that a group of MS immunopathic trait individuals, siblings to MS patients, are essentially free from the central nervous system functional loss typically found in MS.