Journal of Neuroimmunology, Vol. 133 (1-2) (2002) pp. 144-150
Eric V. Yang a, Cynthia M. Bane b 1 , Robert C. MacCallum b,c, Janice K. Kiecolt-Glaser c,d,e, William B. Malarkey c,d,e,f and Ronald Glaser a,c,e
a Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, 2175 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210, USA
b Department of Psychology, The Ohio State University, 1670 Upham Dr., Columbus, OH 43210, USA
c Institute of Behavioral Medicine Research, The Ohio State University, 1670 Upham Dr., Columbus, OH 43210, USA
d Department of Psychiatry, The Ohio State University, 300 W 10th Avenue, Columbus, OH 43210, USA
e Comprehensive Cancer Center, The Ohio State University, 410 W 10th Avenue, Columbus, OH 43210, USA
f Department of Internal Medicine, The Ohio State University, 333 W 10th Avenue, Columbus, OH 43210, USA
Matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs), whose expression can be controlled by cytokines, play a role in extracellular matrix remodeling in physiological and pathological processes.
Using a blister chamber wound model on UV-B-exposed human forearm skin, we examined whether stress or mood-associated neuroendocrine alteration is sufficient to modulate MMP and TIMP expression.
We did not find evidence that depressive symptoms were reliably associated with modulation of either MMP or TIMP expression.
However, we did find that activation of the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal medullary (SAM) axes can modulate levels of MMPs.
A positive association between plasma norepinephrine levels and MMP-2 protein levels, and a negative correlation between plasma cortisol levels and MMP-2 levels were found.
The data suggest that activation of the HPA and SAM axes, even in individuals within the normal range of depressive symptoms, could mediate MMP levels and wound healing in blister wounds.
© Copyright 2002, Elsevier Science