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More MS news articles for November 2002

Pecam-1 expression in patients with relapsing-remitting multiple sclerosis

Folia Morphol (Warsz) 2002;61(3):143-5
Niezgoda A, Losy J.
Department of Clinical Neuroimmunology, University School of Medicine, Poznan, Poland.

PECAM-1 is an adhesion molecule--a member of the immunoglobulin superfamily--involved in the transendothelial migration of leukocytes.

PECAM-1 is expressed on lymphocytes, monocytes and granulocytes.

It is also found on endothelial cells and platelets.

We present data showing that the cell-bound form of PECAM-1 expression on monocytes is increased in MS patients, compared to controls.

We also show that PECAM-1 is significantly over-expressed on lymphocytes in patients with active MRI lesions, when compared to those without gadolinium-enhancing lesions.

Our results suggest that the cell-bound form of PECAM-1 can be regarded as a marker of MS activity.