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More MS news articles for November 2002

Monofocal acute inflammatory Demyelination (MAID): a unique disorder simulating brain neoplasm

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12425506&dopt=Abstract

South Med J 2002 Oct;95(10):1180-6
Gutrecht JA, Berger JR, Jones RH Jr, Mancall AC.
Department of Neurology, Lahey Clinic Medical Center, Burlington, Mass, USA.

BACKGROUND:

Monofocal acute inflammatory demyelinating (MAID) lesions present as large masses that mimic brain tumors. The natural history and nosologic classification are not well defined.

METHODS:

Five patients with MAID from our files and 4 from the literature are presented. We defined MAID as a mass-like lesion, >4 cm in diameter. Demyelination was pathologically proven in all patients.

RESULTS:

Headaches and motor deficits were the most common presenting symptoms. Language problems and motor deficits were the most common findings on physical examination. After a median follow-up of 44 months, none of our 5 patients had multiple sclerosis. In similar cases, additional lesions indicative of multiple sclerosis developed within an average of 8 months.

CONCLUSIONS:

It may be difficult to distinguish MAID from brain tumor. It may be that MAID represents a unique form of isolated demyelinating disease, or it may represent transition to multiple sclerosis.