Journal of Neuroimmunology, Vol. 132 (1-2) (2002) pp. 123-128
Nitza Lahat a,b,c, Sarah Shapiro c, Paul Froom d,e, Estela Kristal-Boneh d, Michael Inspector f and Ariel Miller a,b,f
a Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
b Rappaport Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Haifa, Israel
c Immunology Research Unit, Lady Davis Carmel Medical Center, Haifa, Israel
d National Institute of Environmental and Occupational Health, Raanana, Sackler School of Medicine, Tel-Aviv University, Ramat Aviv, Israel
e Department of Epidemology and Preventative Medicine, Sackler School of Medicine, Tel-Aviv University, Ramat Aviv, Israel
f Neuroimmunology Research Unit, Lady Davis Carmel Medical Center, Haifa, Israel
Inorganic lead (Pb) is a ubiquitous environmental contaminant that produces a variety of deleterious effects in the central nervous system (CNS).
Matrix metalloproteinases (MMPs), specifically MMP-9, induced by inflammatory cytokines, are increasingly being implicated in CNS pathology.
The present study demonstrates that low concentrations of either pro-inflammatory cytokines (TNF-a and IL-1b) or Pb did not influence the MMP-9 expression in a glial cell line (C6) when added separately.
However, combined administration of Pb and cytokines induced a marked synergized elevation of MMP-9 expression in spite of a reduction in the number of glial cells.
These results demonstrate a possible new mechanism by which Pb may induce neuropathological processes.