Journal of Neuroimmunology, Vol. 132 (1-2) (2002) pp. 117-122
Hui Shao, Sheher L. Sun, Henry J. Kaplan and Deming Sun
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, 301 E. Muhammad Ali Blvd., Louisville, KY 40202, USA
Previous studies have shown that immunization of the Lewis rat with myelin basic protein (MBP), an encephalitogenic antigen derived from the myelin sheath of the CNS, induced both experimental autoimmune encephalomyelitis (EAE) and anterior uveitis (AU).
In the current study, we show that a major peptide derived from another encephalitogenic myelin protein - the myelin/oligodendrocyte glycoprotein (MOG35-55)-induced both encephalomyelitis and uveitis in (B6×SJL) F1 and wt-B6 mice.
Pathological studies documented that an anterior uveitis was induced by MOG35-55.
A similar disease pattern was induced by either active immunization with peptideMOG35-55 (pMOG35-55) or adoptive transfer of MOG35-55-specific T cells.
The induced uveitis persisted for >60 days without remission.
Our studies demonstrate for the first time that MOG is uveitogenic in mice that express the H-2b genetic background.
This new experimental model should provide a useful tool for the study of the pathogenesis of chronic AU and determination of the pathogenic mechanisms by which a large portion of MS patients develops uveitis.