Journal of Neuroimmunology, Vol. 133 (1-2) (2002) pp. 151-159
Enrico Fainardi a , Enrico Granieri a, Maria Rosaria Tola a, Loredana Melchiorri b, Luca Vaghi a, Roberta Rizzo b, Massimiliano Castellazzi a, Stefano Ceruti c, Ezio Paolino a and Olavio Roberto Baricordi b,d
a Multiple Sclerosis Center, Department of Neurology, University of Ferrara, Arcispedale S. Anna, Corso della Giovecca 203, Ferrara I-44100, Italy
b Department of Experimental and Diagnostic Medicine-Section of Medical Genetics, University of Ferrara, via Luigi Borsari 46, Ferrara I-44100, Italy
c Section of Neuroradiology, Department of Neurosciences, Azienda Ospedaliera-Universitaria, Arcispedale S. Anna, Corso della Giovecca 203, Ferrara I-44100, Italy
d Biotechnology Center, University of Ferrara, via Luigi Borsari 46, Ferrara I-44100, Italy
The goal of our study was to clarify the contribution of soluble human leukocyte antigens class I (sHLA-I) in multiple sclerosis (MS) immune dysregulation.
We retrospectively evaluated by ELISA cerebrospinal fluid (CSF) and serum sHLA-I levels in 79 relapsing-remitting (RR), 26 secondary progressive (SP) and 15 primary progressive (PP) MS patients stratified according to clinical and Magnetic Resonance Imaging (MRI) evidence of disease activity.
One hundred and nine patients with other inflammatory neurological disorders (OIND), 88 with noninflammatory neurological disorders (NIND) and 82 healthy donors were used as controls.
An intrathecal synthesis of sHLA-I detected by a specific index was significantly more consistent in MS than in controls, with more pronounced values in MS patients with relapses and MRI enhancing brain lesions.
A decrease in serum sHLA-I concentrations was observed in MS patients with demyelinating attacks, while an increase in CSF levels of sHLA-I was found in MS patients with lesional activity on MRI scans.
This association between intrathecal synthesis and reciprocal fluctuations of CSF and serum levels of sHLA-I in clinically and MRI active MS seems to suggest a potential role for CSF and serum levels of sHLA-I as a sensitive marker of immune activation taking place both intrathecally and systemically in MS.
© Copyright 2002, Elsevier Science