Journal of Neuroimmunology, Vol. 133 (1-2) (2002) pp. 95-107
Ruaidhrí J. Carmody a, Brendan Hilliard a, Kimberly Maguschak a, Lewis A. Chodosh b and Youhai H. Chen a
a Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
b Departments of Cancer Biology and Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Blvd., Philadelphia, PA 19104, USA
Using gene microarray technology, we found that inflammation in the central nervous system (CNS) not only induced the expression of many immune-related genes, but also significantly altered the gene expression profile of neural cells.
Two unique groups of CNS genes were identified.
The first group includes genes encoding ion channels, neural transmitters and growth factors.
The second group includes genes that are important for nervous tissue regeneration.
Additionally, a distinct pattern of gene expression was also identified in recovering animals.
Thus, during autoimmune inflammation, the CNS actively responds to immune attacks by activating its own defense and repair genes.
© 2002 Elsevier Science B.V.