Journal of Neuroimmunology, Vol. 133 (1-2) (2002) pp. 184-192
Hui-Yun Wang a, Makoto Matsui a, Shin-ichi Araya a, Nobuyuki Onai b, Kouji Matsushima b and Takahiko Saida a
a Department of Neurology and Clinical Research Center, Center for Neurological Diseases, Utano National Hospital, Ukyo, Kyoto 616-8255, Japan
b Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, Tokyo
Thirty-four patients with early relapsing-remitting multiple sclerosis (RRMS) were studied to clarify the differences in chemokine receptor usage by blood and cerebrospinal fluid (CSF) lymphocytes relevant to the pathogenesis of MS.
A total of 45 examinations (33 active and 12 inactive stages) revealed that circulating CD4+CXCR3+ T helper 1 (Th1) cells were increased in active MS patients and correlated with the number of gadolinium-enhanced lesions on magnetic resonance (MR) images.
In contrast, CSF samples obtained during active stages were characterized by a decrease in the percentage of CD8+CXCR3+ T cells, which was inversely correlated with CSF cell count and intra-blood-brain barrier (BBB) IgG production.
© Copyright 2002, Elsevier Science