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More MS news articles for November 2002

In Vitro Detection of Apoptosis in Monocytes/Macrophages Infected with Human Coronavirus

Clin Diagn Lab Immunol 2002 Nov;9(6):1392-1395
Collins AR.
Department of Microbiology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214.

Human coronavirus (HCoV) strain 229E infection, but not HCoV strain OC43 infection, of monocytes/macrophages from healthy donors and patients with multiple sclerosis in remission resulted in increased apoptosis, as measured by DNA changes and annexin V staining.

Apoptosis correlated with the differential release of infectious virus.

HCoV strain 229E titers were 10(3.5) to 10(6) 50% tissue culture-infective doses (TCID(50))/ml, and HCoV strain OC43 titers were only 10(1.2) to 10(2.7) TCID(50)/ml.