http://www3.interscience.wiley.com/cgi-bin/abstract/86511526/START

Journal of Neuroscience Research
Volume 66, Issue 3, 2001. Pages: 506-509
T. Vu, L.W. Myers, G.W. Ellison, F. Mendoza, J.M. Bronstein *
Department of Neurology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, California

Abstract

Oligodendrocyte-specific protein (OSP) is concentrated in CNS myelin and is a potential autoantigen in the development of multiple sclerosis (MS).

We performed proliferation assays with lymphocytes from MS patients and normal controls.

OSP peptide-induced proliferation was common in relapsing-remitting MS and controls samples but was less pronounced in samples from secondary progressive MS subjects.

These data demonstrate that OSP-reactive T cells are part of the normal immune repertoire and therefore have the potential to contribute to the pathogenesis of MS.

Given the lack of specificity to MS, OSP-reactive T-cells are unlikely to be solely responsible for the disease process.

J. Neurosci. Res. 66:506-509, 2001.

Funded by:
 NIH; Grant Number: NS01596
 National Multiple Sclerosis Society; Grant Number: RG2850B1
 Conrad Hi Hon Foundation
 Nancy Davis Center Without Walls
 

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