Acta Neurologica Scandinavica 104
(5), 262-265
Department of Neurology, University
Hospital, S-22185 Lund, Sweden
Objectives
The etiology of MS is unknown but
genetic factors are supported by a high concordance in twins. Geographic
distribution and migration studies indicate, however, the importance of
environmental factors.
Material and methods
We studied 3 pairs of genetically
identical twins who had shared the same environment but were discordant
for MS. Serum samples were assayed for antibodies against 21 viruses, 4
bacteria and Toxoplasma gondii.
Results and conclusion
No common factor present only in
the affected twins was identified but differences were found in serum titers
against some neurotropic microorganisms. In general the serum titers were
strikingly similar in the twins, indicating no major disturbances of the
humoral immune system in MS.
© Munksgaard 2001
M. Bergkvist and M. Sandberg-Wollheim