More MS news articles for Nov 2001

Modelling new enhancing MRI lesion counts in multiple sclerosis

http://www.ingenta.com/isis/searching/ExpandTOC/ingenta?issue=infobike://arn/ms/2001/00000007/00000005&index=5&WebLogicSession=O2A1TTLzRXDjqMzyZm8D|-2366265230036197976/-1052814329/6/7051/7051/7052/7052/7051/-1

Multiple Sclerosis,
October 2001,
vol. 7, no. 5,   pp. 298-304(7)
Sormani M.P. [2]; Bruzzi P. [1]; Rovaris M. [2]; Barkhof F. [4]; Comi G. [3]; Miller D.H. [5]; Cutter G.R. [6]; Filippi M. [2] *
[1] Unit of Clinical Epidemiology and Trials, National Institute for Cancer Research, Genoa, Italy
[2] Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale and University San Raffaele, Milan, Italy
[3] Clinical Trials Unit, Department of Neuroscience, Scientific Institute Ospedale and University San Raffaele, Milan, Italy
[4] Dutch MS/MR Center, Free University Hospital, Amsterdam, The Netherlands
[5] NMR Research Unit, Institute of Neurology, London, UK
[6] Center for Research Methods and Biometrics, AMC Cancer Research Center, Lakewood, Colorado, USA
[*] Correspondence: M Filippi, Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale san Raffaele, Via Olgettina 60, 20132 Milan, Italy

Abstract:

Magnetic resonance imaging (MRI) has been established as the most relevant paraclinical tool for diagnosing and monitoring multiple sclerosis (MS).

In this context, counting the number of new enhancing lesions on monthly MRI scans is widely used as a surrogate marker of MS activity when evaluating the effect of treatments.

In this study, we investigated whether parametric models based on mixed Poisson distributions (the Negative Binomial (NB) and the Poisson-Inverse Gaussian (P-IG) distributions) were able to provide adequate fitting of new enhancing lesion counts in MS.

We found that the NB model gave good approximations in relapsing remitting and secondary progressive MS patients not selected for baseline MRI activity, whereas the P-IG distribution modelled better new enhancing lesion counts in relapsing remitting MS patients selected for baseline activity.

This study shows that parametric modelling for MS new enhancing lesion counts is feasible.

This approach should provide more targeted tools for the design and the analysis of MRI monitored clinical trials in MS.
 

© 2001 ingenta