More MS news articles for Nov 2001

A case of multiple sclerosis triggered by organic solvents

Neurological Sciences
Abstract Volume 22 Issue 2 (2001) pp 155-158
J. Reis (1), J. L. Dietemann (1)(2), J. M. Warter (1)(3), C. M. Poser (4)
(1) 23 Rue du Marquis de Chamborand, 57200 Sarreguemines, France
(2) Department of Neuroradiology, University Hospital, Strasbourg, France
(3) Department of Neurology, University Hospital, Strasbourg, France
(4) Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA


The neurotoxicity of organic solvents has long been recognized.

Some are used as anesthetic agents, others in various industries.

Their acute effect has been well documented since the nineteenth century, but more recently they have become notorious as the cause of addiction to glue sniffing.

They may alter the immune system by causing lymphopenia, impairing phagocytosis and decreasing the level of serum complement, as well as altering the impermeability of the blood-brain barrier and leading to the appearance of white matter lesions in the brain.

The following case study explores the possible role of organic solvents in the pathogenesis of multiple sclerosis.

© Springer-Verlag Italia 2001