More MS news articles for Nov 2001

Insights into autoimmunity gained from structural analysis of MHC-peptide complexes

Curr Opin Immunol 2001 Dec 1;13(6):650-656
Wucherpfennig KW.
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Room D1410, 44 Binney Street, 02115, Boston, MA, USA

The structural and functional properties of HLA-DQ and -DR molecules that confer susceptibility to several common autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis and multiple sclerosis, have been defined.

The relevant polymorphisms directly affect interaction with peptides, which provides strong support for the hypothesis that these diseases are peptide-antigen driven.

Several studies indicate that structural modifications of peptides can affect MHC class II binding and/or TCR recognition and should be considered in the analysis of T cell responses in autoimmune diseases.

PMID: 11677085 [PubMed - as supplied by publisher]