More MS news articles for Nov 2001

IFN-beta1a Modulates the Expression of CTLA-4 and CD28 Splice Variants in Human Mononuclear Cells: Induction of Soluble Isoforms

J Interferon Cytokine Res 2001 Oct;21(10):809-12
Giorelli M, Livrea P, Defazio G, Ricchiuti F, Pagano E, Trojano M.
Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy.

Recently, mRNA encoding soluble isoforms of CD28 and CTLA-4 have been described in human lymphocytes.

We demonstrate that interferon-beta1a (IFN-beta1a) can enhance the expression of these transcripts in human mononuclear cells.

Because soluble CD28 and CTLA-4 molecules might affect T cell activation, our findings suggest an additional means whereby IFN-beta therapy might exert its immunomodulatory effects in multiple sclerosis (MS).

PMID: 11710992 [PubMed - in process]