More MS news articles for Nov 2001

Clues to the immunopathogenesis of multiple sclerosis by investigating untreated patients during the very early stage of disease

Neurological Sciences
Abstract Volume 22 Issue 2 (2001) pp 145-149
M. Söderström
Department of Ophthalmology and Neuroimmunology Unit, Division of Neurology, Huddinge University Hospital, Huddinge, Sweden and Karolinska Institute, S-14186 Stockholm, Sweden


Plethora of abnormalities of the immune system has been described in multiple sclerosis (MS).

They include

However, no consistent patterns have emerged that relate any of these findings to clinical variables such as exacerbations, during of disease, disability, or lesions in the central nervous system (CNS) detected at magnetic resonance imaging.

In order to elucidate the relevance of these immunological abnormalities in the pathogenesis of MS, my colleagues and I studied patients with acute monosymptomatic optic neuritis (ON) and compared them with patients with clinically definite MS (CDMS).

The patients have not been treated and have not received corticosteroids or interferon-<beta>.

When comparing these two groups, we were unable to identify any differences in any of the variables mentioned.

Thus, very early MS, as represented by ON, shows the same full-blown pattern of immunological abnormalities seen in CDMS.

Furthermore, a complete epitope spread affecting MBP, MOG, PLP, MAG and other myelin components is already present in ON.

Whether any of these alterations play a pathogenetic role is still unsettled.

© Springer-Verlag Italia 2001