Abstract Volume 22 Issue 2 (2001) pp 145-149
Department of Ophthalmology and Neuroimmunology Unit, Division of Neurology, Huddinge University Hospital, Huddinge, Sweden and Karolinska Institute, S-14186 Stockholm, Sweden
Plethora of abnormalities of the immune system has been described in multiple sclerosis (MS).
In order to elucidate the relevance of these immunological abnormalities in the pathogenesis of MS, my colleagues and I studied patients with acute monosymptomatic optic neuritis (ON) and compared them with patients with clinically definite MS (CDMS).
The patients have not been treated and have not received corticosteroids or interferon-<beta>.
When comparing these two groups, we were unable to identify any differences in any of the variables mentioned.
Thus, very early MS, as represented by ON, shows the same full-blown pattern of immunological abnormalities seen in CDMS.
Furthermore, a complete epitope spread affecting MBP, MOG, PLP, MAG and other myelin components is already present in ON.
Whether any of these alterations
play a pathogenetic role is still unsettled.
© Springer-Verlag Italia 2001