More MS news articles for Nov 2001

Bone Marrow Transplantation for Non-Malignant Disease

Hematology (Am Soc Hematol Educ Program) 2000;:319-338
Sullivan KM, Parkman R, Walters MC.

This article reviews the experience in hematopoietic stem cell transplantation (HSCT) for non-malignant disease.

HSCT has long been applied as treatment of life-threatening congenital immunodeficiency and metabolic diseases.

In Section I, Dr. Parkman reviews that experience for severe combined immunodeficiency, Wiscott-Aldrich syndrome, hyper IGM syndrome, Chediak-Higashi disease and hereditary lymphohistiocytosis.

The value of HSCT in genetic metabolic diseases such as osteopetrosis, osteogenesis imperfecta and the storage diseases are reviewed.

In Section II, Dr. Walters reviews the experience over the last decade with allogeneic stem cell transplantation in patients with thalassemia major and sickle cell disease.

In Section III, Dr. Sullivan reviews the more recent investigations using stem cell transplantation in patients with advanced autoimmune diseases such as systemic sclerosis, systemic lupus erythematosus, multiple sclerosis and juvenile rheumatoid arthritis.

The pathogenesis and outcome with conventional care of these patients, the selection criteria and current results for HSCT, and the future directions in clinical research and patient care using this modality are addressed.

PMID: 11701549 [PubMed - as supplied by publisher]