More MS news articles for Nov 2001

A preliminary result of treatment of progressive multiple sclerosis with autologous peripheral blood stem cell transplantation in China

Zhonghua Nei Ke Za Zhi 2001 Aug;40(8):550-2
Ouyang J, Ni X, Chen B.
Department of Hematology, Affiliated Drum Tower Hospital of School Medicine, Nanjing University, Nanjing 210008, China.


To explore the clinical effect for treatment of progressive multiple sclerosis (PMS) by autologous peripheral blood stem cell transplantation (Auto-PBSCT).


One PMS patient was chosen. Peripheral blood stem cells (PBSCs) were mobilized with cyclophosphamide and G-CSF. The CD34+ cells harvesting was performed by continuous flow leukapheresis using a CS3000 plus blood separator. About 12.2 x 10(6) CD34+ cells/kg was collected and preserved at -196 degrees C in liquid nitrogen. PBSCs were reinfused after conditioned by CTX (120 mg/kg) and TBI(10 GY). G-CSF was used to help hematopoietic and immunologic reconstitution.


After transplantation the patient received clinical remission, and the abnormal signals of MRI in T1-T4 disappeared, the examination results of the neuro-electrophysiology and T cell subgroup were improved obviously. There was no relapse after 6 months follow up.


Auto-PBSCT is effective and safety for PMS. Duration of remission remains to be decided in long-term follow up.

PMID: 11718058 [PubMed - in process]