More MS news articles for Nov 2001

A preliminary result of treatment of progressive multiple sclerosis with autologous peripheral blood stem cell transplantation in China

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11718058&dopt=Abstract

Zhonghua Nei Ke Za Zhi 2001 Aug;40(8):550-2
Ouyang J, Ni X, Chen B.
Department of Hematology, Affiliated Drum Tower Hospital of School Medicine, Nanjing University, Nanjing 210008, China.

OBJECTIVE:

To explore the clinical effect for treatment of progressive multiple sclerosis (PMS) by autologous peripheral blood stem cell transplantation (Auto-PBSCT).

METHODS:

One PMS patient was chosen. Peripheral blood stem cells (PBSCs) were mobilized with cyclophosphamide and G-CSF. The CD34+ cells harvesting was performed by continuous flow leukapheresis using a CS3000 plus blood separator. About 12.2 x 10(6) CD34+ cells/kg was collected and preserved at -196 degrees C in liquid nitrogen. PBSCs were reinfused after conditioned by CTX (120 mg/kg) and TBI(10 GY). G-CSF was used to help hematopoietic and immunologic reconstitution.

RESULTS:

After transplantation the patient received clinical remission, and the abnormal signals of MRI in T1-T4 disappeared, the examination results of the neuro-electrophysiology and T cell subgroup were improved obviously. There was no relapse after 6 months follow up.

CONCLUSIONS:

Auto-PBSCT is effective and safety for PMS. Duration of remission remains to be decided in long-term follow up.
 

PMID: 11718058 [PubMed - in process]