Zhonghua Nei Ke Za Zhi 2001 Aug;40(8):550-2
Ouyang J, Ni X, Chen B.
Department of Hematology, Affiliated
Drum Tower Hospital of School Medicine, Nanjing University, Nanjing 210008,
China.
OBJECTIVE:
To explore the clinical effect for
treatment of progressive multiple sclerosis (PMS) by autologous peripheral
blood stem cell transplantation (Auto-PBSCT).
METHODS:
One PMS patient was chosen. Peripheral
blood stem cells (PBSCs) were mobilized with cyclophosphamide and G-CSF.
The CD34+ cells harvesting was performed by continuous flow leukapheresis
using a CS3000 plus blood separator. About 12.2 x 10(6) CD34+ cells/kg
was collected and preserved at -196 degrees C in liquid nitrogen. PBSCs
were reinfused after conditioned by CTX (120 mg/kg) and TBI(10 GY). G-CSF
was used to help hematopoietic and immunologic reconstitution.
RESULTS:
After transplantation the patient
received clinical remission, and the abnormal signals of MRI in T1-T4 disappeared,
the examination results of the neuro-electrophysiology and T cell subgroup
were improved obviously. There was no relapse after 6 months follow up.
CONCLUSIONS:
Auto-PBSCT is effective and safety
for PMS. Duration of remission remains to be decided in long-term follow
up.
PMID: 11718058 [PubMed - in process]